3rd dose: does the vaccine mix present any risk?

Many Quebecers who received the Pfizer or AstraZeneca vaccines in the first and second doses were recently offered a Modern vaccine in the third dose, which raised some questions.

• See also: LIVE | The latest news on the coronavirus

• To also read: RNA vaccines: confirmed but rare risk of myocarditis and pericarditis according to study

Is this mix of different types of vaccines effective in fighting COVID-19 or does it pose risks?

According to Alain Lamarre, immunologist at the National Institute for Scientific Research (INRS), this way of doing things is “safe”, support studies on this topic.

“There are no more important side effects than receiving the same vaccine two or three times, and the efficacy is comparable,” explains the scientist in an interview with Quebec Matin.

He goes further. “Even those who received AstraZeneca and subsequently Pfizer had a better immune response than those who received AstraZeneca alone,” he notes.

“There is even a theoretical advantage of receiving the vaccine mixtures, it stimulates different pathways of the immune system and could protect us better, although we do not have much data on this subject.”

Additionally, Moderna would present a slightly higher risk of pericarditis for young men, an inflammation of the heart.

“There are girls, but it is more common among young boys between the ages of 18 and 29. We are talking about a very minimal risk, on the order of fifteen events per 100,000 inhabitants, while for Pfizer, we are talking about five events per 100,000 inhabitants ”, explains Mr. Lamarre.

So the risk is low, but slightly higher with the Moderna vaccine. Those under 30 should prefer Pfizer if available.

Alain Lamarre, however, maintains that it is better to take your third dose of vaccine as soon as possible, even if it is Moderna.

“If I were between 18 and 30 years old, I would not doubt it. […] The cases of myocarditis are treatable and it does not last long either ”, he concludes.

*** See his full explanation in the video above. ***


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