Covid: high efficacy of vaccines against severe cases of Omicron, according to US data – Sciences et Avenir

Vaccines and booster doses against Covid-19 continued to have very high efficacy against severe cases of the disease during the wave caused by the Omicron variant, a large US study said on Friday.

This study from the Centers for Disease Control and Prevention (CDC) reviews data from more than 300,000 emergency room visits, urgent care clinics, and hospitalizations in 10 states since 26 August 2021 until January 5, 2022.

During the period when the Delta variant was dominant, vaccine efficacy against Covid-19 hospitalizations was 90% between 14 and 179 days after the second dose of a vaccine. It fell to 81% for 180 days after the second dose and increased to 94% 14 or more days after the third.

Once Omicron became dominant, the vaccine’s efficacy against hospitalizations between 14 and 179 days after the second dose was estimated to be 81%; it was 57% after more than 180 days after the second dose and 90% 14 days or more after the third.

A second study, based on data from 25 US states and local jurisdictions, shows that vaccine efficacy against infections increased from 93%, before Delta, to around 80% once Delta became dominant ; but protection against death remained stable, and high, at 94%.

The efficacy against infections was reduced to 68% with Omicron. The authors were unable to derive an estimate of the vaccine’s protection against death during Omicron due to a delay in recording the information, but the scientists expect it to remain very high.

The study also shows that while deaths among fully vaccinated people rose sharply during the Delta wave (more than 20,000 people between July and November), unvaccinated people were 16 times more likely to die during the same period.

The protection was even greater for people who received a booster dose. Between October and November, unvaccinated people were 50 times more likely to die from Covid than vaccinated people who received a booster.

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