COVID-19

COVID VACCINE: Increased risk of carditis?

Carditis is a rare inflammation of the heart often caused by bacterial, viral, and parasitic infections. Common subtypes of carditis include myocarditis, inflammation of the heart muscle, and pericarditis, inflammation of the outer lining of the heart. Case reports of carditis after BNT162b2 vaccination have been increasing worldwide. Several studies have also reported similar results, but analytical research on the association with COVID vaccination remains limited.

Cette étude cas-témoins que révèle pour la première fois un risque relatif accru de cardite associé à la vaccination par le vaccin Pfizer/BioNTech et appelle los autorités sanitaires à prendre en compte de ce risque avec une stratégie plus ciblée, qu’une approche « one size “.

The risk of carditis with the Pfizer/BioNTech vaccine remains very low in absolute value

The Hong Kong investigators followed 160 patients with carditis and 1,533 control patients without carditis and examined the possible risk of carditis associated with vaccination with BNT162b2 (Pfizer/BioNTech) or CoronaVac (Sinovac). Ten control patients were matched with each case of carditis based on age, sex, and date of hospital admission. After analysis, the researchers identify:

  • 20 cases of carditis associated with the Pfizer/BioNTech vaccine and 7 associated with vaccination with the CoronaVac vaccine;
  • Patients vaccinated with the BNT162b2 vaccine appear to be 3 times more likely to develop carditis than unvaccinated patients;
  • patients who have received the CoronaVac vaccine have a risk of carditis similar to that of unvaccinated patients (with no increased risk);
  • the increased risk associated with the Pfizer BNT162b2 vaccine appears to be predominant in men and is more likely to be seen after the second dose;
  • the cumulative incidence of carditis after vaccination was 0.57 per 100,000 doses of BNT162b2 and 0.31 per 100,000 doses of CoronaVac: which allows us to conclude, despite the higher risk with the BNT162b2 vaccine, that the absolute risk of carditis after vaccination is very low.

Finally, none of the 20 patients with carditis after BNT162b2 vaccination were admitted to intensive care or died during the observation period.

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