These trials will include a total of 600 adults, half of whom already received two doses of Moderna’s vaccine at least six months ago, and the other half received not only those initial two doses but also at least three months ago, the reinforcement now. authorized.
Therefore, the specific boost against Omicron will be evaluated as a third or fourth dose.
The company also reported results on the effectiveness of the recall already authorized against Omicron.
According to the company, six months after the booster injection, levels of neutralizing antibodies against Omicron dropped six-fold from the peak seen 29 days after the sting, but remained detectable in all participants.
These data were obtained by studying the blood of 20 people who received the 50 microgram booster dose (half of the first two injections).
“We are reassured by the persistence of antibodies against Omicron six months after the currently authorized recall,” Stéphane Bancel, head of Moderna, said in a press release.
“However, given the long-term threat posed by Omicron’s immune evasion, we are moving forward with the withdrawal of our Omicron-specific vaccine candidate,” he added.
The Pfizer-BioNTech alliance also announced this week that it has started trials to test its own specific vaccine against Omicron.
But Pfizer is evaluating its formula not only as a booster, but also for the initial round of injections, in previously unvaccinated people.
These two vaccines are based on messenger RNA technology, which makes it possible, in particular, to be able to update them relatively easily to follow the evolution of the specific mutations of the new variants.
Several countries, including the United States, have begun to see a drop in cases due to the wave caused by Omicron, the most transmissible variant detected at this stage, but the number of contaminations worldwide continues to increase.
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