Molnupinavir: how does the anti-covid pill that arrives in France work? – Numerama

This coronavirus drug will arrive in France in December 2021. Based on molnupinavir, it is the first covid drug that can be taken orally and it can change many things.

When announcing the new measures on the booster dose and the health pass, the Minister of Health Olivier Véran took the opportunity to recall the arrival of the first anticovido drugs by the end of 2021. Confirming the ‘Previous announcement by Emmanuel Macron, Olivier Véran referred to molnupinavir: it is a pill, which can be prescribed from December 2021 by family doctors.

This medicine will be reserved for people at risk for severe forms of the disease.

Our video on anti-covid pills:

The United Kingdom was the first country in which molnupinavir became available. In France, Health Minister Olivier Véran announced that he had requested 50,000 doses.

The Merck pill is an antiviral, curative.

The drug is an antiviral, which means that it works after an infection has occurred. When a virus contaminates the body, it replicates within cells. To prevent it from causing harm, you have to interrupt that replication cycle, and that’s where antivirals come in.

In this case, the pill developed by Merck laboratories is based on molnupinavir. This drug was originally known to treat hepatitis C and influenza. Very early in the history of coronavirus research, trials have shown that molnupinavir is potentially effective against Covid-19 disease. It has been tested first in mice, then in phase 2 and phase 3 human clinical trials. The Merck laboratory claims, after studies, that it reduces the risk of death or dying by 50%.

So far, Merck’s pill is the first oral coviditis drug to be approved in a country. // Source: Pexels

Molnupinavir inserts errors during the replication of the coronavirus viral RNA, making any new copies of the virus based on the altered RNA less efficient than before. One thing led to another, therefore the drug mutates the coronavirus until it dies.

What could molnupinavir change

After studying the data that Merck sent it, the British health authority, where the drug was validated for the first time in the world, concluded that the drug was “safe and effective in reducing the risk of hospitalization and death in people with mild or moderate “. 19 and at a higher risk of developing a serious disease. “

This drug has several advantages, the first is that it is taken orally. This is the first time, because previously approved treatments for COVID were injected intravenously. Oral treatment can be administered outside the hospital setting and therefore as early as possible in the progression of the disease.

The UK Department of Health said the drug could make a difference for the most vulnerable and immunosuppressed; that also affirmed, in France, Olivier Véran. Indeed, this is the case: these patient profiles, in which the immune system is failing, are the ones most at risk should Covid-19 disease develop. For these people, the vaccine may not always be enough to boost the immune system. The risk is then that serious or long forms reach them. An effective and safe drug that can be taken soon after infection has the advantage of preventing a serious version of the disease.

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