OSE Immunotherapeutics generates hope. The Nantes laboratory took stock of the first positive results and the clinical development of CoVepiT, its multi-target anti-Covid T vaccine. New clinical data confirm the good tolerance of CoVepiT and a very good level of T cell response in healthy vaccinated volunteers. Promising preclinical signs of efficacy are guiding development in immunosuppressed patients with poor antibody responses to COVID vaccines already on the market.
Long-term memory T response results at 6 months, expected in the first quarter of 2022, will be a key element in subsequent clinical development. CoVepiT epitopes remain independent of identified mutations in current and emerging variants. These epitopes, viral protein fragments, are antigenic determinants recognized by T cell receptors during an adaptive T immune response. They are not currently affected by the mutations described for existing (Delta) and emerging (Omicron) variants.
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