Vaccine. Covid-19: what are the side effects of the third dose?

Pain at the injection site, headache, fatigue, fever … The first 2 injections of the Covid-19 vaccine were marked by the appearance of mild to moderate side effects that disappeared spontaneously within a few days.

Other manifestations, more serious but also rarer (hypersensitivity reactions, for example) have also been described.

What to expect with the 3rd dose that will be generalized in France?

What vaccines for the booster?

Booster injections should only be done with mRNA vaccines (Pfizer-BioNTech or Moderna). These two vaccines can be used independently of the vaccine used in the context of the first vaccination schedule.

The third dose of Pfizer has the same formulation and strength as the first 2 injections. With respect to Moderna, the booster corresponds to a dose reduced by half.

Similar effects

To know the possible side effects of this third dose, it is best to go to the United States where the recall campaign began last September.

Thus, the Centers for Disease Control (Atlanta CDC) analyzed, in 12,600 volunteers, the frequency of appearance of side effects after the third injection.

79.4% of those who received the third dose reported injection site reactions, such as pain or swelling, compared with 77.6% for the second.

In contrast, slightly fewer experienced systemic reactions, such as fever or headache: 74.1% (3rd dose) versus 76.5% (2nd dose).

“Most of the local and systemic reactions were mild to moderate, transient, and most frequently reported the day after vaccination,” the CDC notes.

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