COVID-19

Vaccine: remember from Pfizer or Johnson & Johnson, which is more effective?

A Johnson & Johnson booster dose increases the effectiveness of this vaccine to 85% in preventing severe cases of Covid-19 against Omicron, according to a study conducted in South Africa, where this variant is ultra-dominant.

“The effectiveness of the vaccine against hospitalizations increases after the injection of the booster dose,” reaching 85% one or two months after this second injection, according to the study published this Thursday on the prepublication site medRxiv.

The study, which has not yet been peer-reviewed, was conducted by the South African Medical Research Council (SAMRC) on healthcare workers from November 15 to December 20.

Nearly half a million South African caregivers had previously received a dose of J & J’s vaccine in clinical trials, and then some of them subsequently received a booster dose, six to nine months after, the first injection.

The effectiveness of the booster against Omicron was determined by comparing a group of 69,000 caregivers who received the booster, with unvaccinated people, in the nine provinces of the country.

Protection against hospitalization increased over time, from 63% between zero and 13 days after the booster injection, to 85% one to two months later.

“These data are important given the increasing dependence (on this vaccine) in Africa,” the study authors wrote.

“The effectiveness of the Johnson & Johnson anti-Covid vaccine remains strong and stable over time, even against circulating variants such as Omicron and Delta,” the US laboratory said in a press release.

In early December, another South African study showed that the US laboratory Pfizer vaccine provided 70% protection against severe cases of Omicron-related disease, but with two doses. The efficacy results of Pfizer with three doses have not yet been published.

Comparison with Pfizer

Johnson & Johnson also announced the results of a second study, involving a few dozen people who were vaccinated for the first time with Pfizer, in order to compare the effect of a Johnson & Johnson booster on them compared to a third dose of Pfizer.

Two weeks after the third injection, the Pfizer booster produced more neutralizing antibodies against Omicron than the J&J booster. But four weeks later, Pfizer’s booster antibodies declined to just a 17-fold increase, while J & J’s had continued to rise, to a 41-fold increase.

The withdrawal of Johnson & Johnson also increased the number of T cells, cells crucial in the body’s defense against the virus, more than that of Pfizer.

These combined results are good news for J&J, which suffered a severe blow to its image in early December, when the United States recommended prioritizing Pfizer and Moderna vaccines over Johnson & Johnson’s.

This US decision was based on the increased risk of thrombosis (formation of blood clots) after vaccination with Johnson & Johnson, which has caused several deaths.

However, the health authorities had stressed that, in the event that no other vaccine was available, the “J&J” vaccine always presented more benefits against Covid-19 than risks.

“The efficacy of the vaccine against hospitalizations increases after the injection of the booster dose”, reaching 85% one or two months after this second injection, according to the study published this Thursday on the prepublication site medRxiv. for peer review, it was conducted by the South African Medical Research Council (SAMRC) on healthcare workers from November 15 to December 20. Nearly half a million South African caregivers had previously received a dose of J & J’s vaccine in clinical trials, and then some of them subsequently received a booster dose, six to nine months after, the first injection. The effectiveness of the booster against Omicron was determined by comparing a group of 69,000 caregivers who received the booster with unvaccinated people in the nine provinces of the country. The protection conferred against hospitalizations increased over time. From 63% between zero and 13 days after the booster injection, to 85% one or two months later. “These data are important given the increasing dependence (on this vaccine) in Africa,” the study authors wrote. “The efficacy of the Johnson & Johnson anti-Covid vaccine remains strong and stable over time, even against circulating variants such as Omicron and Delta,” the US laboratory said in a press release. In early December, another study The South African study showed that the US laboratory Pfizer vaccine provided 70% protection against severe cases of Omicron-related disease, but with two doses. The efficacy results of Pfizer with three doses have not yet been published. Comparison with Pfizer Johnson & Johnson has also reported the results of a second study, involving a few dozen people who were vaccinated for the first time with Pfizer, in order to compare the effect on them of a Johnson & Johnson booster versus a third dose of Pfizer Two weeks after the third injection, the Pfizer booster produced more neutralizing antibodies against Omicron than the J&J booster. But four weeks later Now, Pfizer’s booster antibodies were dropping to just a 17-fold increase, while J & J’s had continued to rise, to a 41-fold increase. The Johnson & Johnson boost also increased more than Pfizer’s T-lymphocyte count – the cells are crucial in the body’s defense against the virus. These combined results are good news for J&J, which suffered a severe blow to its image in early December, when the United States recommended prioritizing Pfizer and Moderna vaccines over Johnson & Johnson’s. The US decision was based on the increased risk of thrombosis (formation of blood clots) after vaccination with Johnson & Johnson, which resulted in several deaths, but health officials had emphasized that, in the absence of another vaccine available, the “J&J” The vaccine always presented more benefits against Covid-19 than risks “.

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